Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26801212 | 0.81 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL9948788 | 0.76 | P2RX7 (0.37) | P2RX7 | |
| SCHEMBL23511758 | 0.73 | HDAC6 (0.41) | P2RX7 | |
| SCHEMBL6221739 | 0.71 | P2RX7 (0.64) | P2RX7 | |
| SCHEMBL24590169 | 0.71 | HCAR2 (0.46) | — | |
| SCHEMBL6382380 | 0.71 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL11744903 | 0.68 | P2RX7 (0.39) | P2RX7 | |
| SCHEMBL147228 | 0.67 | — | — | |
| SCHEMBL4919254 | 0.67 | NPSR1 (0.42) | — | |
| SCHEMBL1961155 | 0.66 | HSP90AA1 (0.38) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043139-B1 | 3-AMINO-5-SUBSTITUTED-6-HALO-N-(3,4-DIHYDRO- OR 4,4-DISUBSTITUTED-6-SUBSTITUTED-1,3,5-TRIAZIN-2-YL)-2-PYRAZINECARBOXAMIDES, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-10-17 | — | — | EP | disclosed |
| EP-0043139-A1 | 3-Amino-5-substituted-6-halo-N-(3,4-dihydro- or 4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides, process for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| US-4272537-A | HYPOTENSIVE AGENTS, ANTIEDEMIC AGENTS | MERCK & CO., INC. (US) | 1981-06-09 | — | — | US | disclosed |