Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11397460 | 0.74 | NOS2 (0.34) | NOS2 | |
| SCHEMBL18532579 | 0.74 | NOS2 (0.34) | NOS2 | |
| SCHEMBL132856 | 0.60 | — | — | |
| SCHEMBL18532580 | 0.57 | NOS2 (0.31) | NOS2 | |
| SCHEMBL18054945 | 0.57 | — | — | |
| SCHEMBL18377027 | 0.55 | — | — | |
| SCHEMBL1035054 | 0.53 | — | — | |
| SCHEMBL18377025 | 0.51 | — | — | |
| SCHEMBL13625374 | 0.49 | NPSR1 (0.43) | — | |
| SCHEMBL1767793 | 0.43 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043139-B1 | 3-AMINO-5-SUBSTITUTED-6-HALO-N-(3,4-DIHYDRO- OR 4,4-DISUBSTITUTED-6-SUBSTITUTED-1,3,5-TRIAZIN-2-YL)-2-PYRAZINECARBOXAMIDES, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-10-17 | — | — | EP | disclosed |
| EP-0043139-A1 | 3-Amino-5-substituted-6-halo-N-(3,4-dihydro- or 4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides, process for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| US-4272537-A | HYPOTENSIVE AGENTS, ANTIEDEMIC AGENTS | MERCK & CO., INC. (US) | 1981-06-09 | — | — | US | disclosed |