Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MPO | P05164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221739 | 0.78 | P2RX7 (0.64) | P2RX7KDM4EMPOCYP3A4CYP1A2 | |
| SCHEMBL1412804 | 0.77 | P2RX7 (0.62) | P2RX7KDM4EMPOSMN1; SMN2GAA | |
| SCHEMBL5159948 | 0.76 | P2RX7 (0.61) | P2RX7KDM4EMPOCYP3A4CYP1A2 | |
| SCHEMBL29253227 | 0.76 | P2RX7 (0.61) | P2RX7KDM4ECYP1A2SMN1; SMN2CTNNB1 | |
| SCHEMBL2363536 | 0.75 | P2RX7 (0.60) | P2RX7KDM4EALDH1A1GAACTNNB1 | |
| SCHEMBL16098187 | 0.75 | P2RX7 (0.60) | P2RX7KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL31589536 | 0.75 | P2RX7 (0.59) | P2RX7KDM4EMPOCYP3A4CYP1A2 | |
| SCHEMBL13359252 | 0.75 | P2RX7 (0.59) | P2RX7KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL930305 | 0.75 | P2RX7 (0.59) | P2RX7KDM4EMPOCYP3A4CYP1A2 | |
| SCHEMBL16027768 | 0.75 | P2RX7 (0.59) | P2RX7KDM4EMPOCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181159-B | 2,4, 5-trisubstituted pyrimidine hydrazide derivative and preparation method and application thereof | 南通大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117003730-A | Substituted pyrimidine hydrazide compound and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2023-11-07 | — | — | CN | claimed |
| WO-2023208018-A1 | SUBSTITUTED PYRIMIDINE HYDRAZIDE COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | 德明药泰生物技术（深圳）有限公司 | 2023-11-02 | — | — | WO | claimed |
| CN-116621783-A | Pyrimidine hydrazide organic gel factor and preparation and application thereof | 上海应用技术大学 | 2023-08-22 | — | — | CN | claimed |
| CN-114181159-A | Hydrazide derivative containing 2,4, 5-trisubstituted pyrimidine, preparation method and application thereof | 南通大学 | 2022-03-15 | — | — | CN | claimed |
| CN-116621783-B | Pyrimidine hydrazide organic gel factor and preparation and application thereof | 上海应用技术大学 | 2026-03-17 | — | — | CN | disclosed |
| CN-116621783-B | Pyrimidine hydrazide organic gel factor and preparation and application thereof | 上海应用技术大学 | 2026-03-17 | — | — | CN | disclosed |
| US-11932683-B2 | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets | NEW YORK UNIVERSITY (US) | 2024-03-19 | — | — | US | disclosed |
| CN-114181159-B | 2,4, 5-trisubstituted pyrimidine hydrazide derivative and preparation method and application thereof | 南通大学 | 2024-02-20 | — | — | CN | disclosed |
| CN-114181159-B | 2,4, 5-trisubstituted pyrimidine hydrazide derivative and preparation method and application thereof | 南通大学 | 2024-02-20 | — | — | CN | disclosed |
| CN-114181159-B | 2,4, 5-trisubstituted pyrimidine hydrazide derivative and preparation method and application thereof | 南通大学 | 2024-02-20 | — | — | CN | disclosed |
| CN-117003730-A | Substituted pyrimidine hydrazide compound and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-1103770-C | Quinoxalinediones | PFIZER RES AND DEV CO N V S A (IE) | 2003-03-26 | — | — | CN | disclosed |
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| CN-1213369-A | Quinoxalinedione compound | PFIZER RES & DEV (IE) | 1999-04-07 | — | — | CN | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |
| EP-0569493-A4 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | — | 1993-11-24 | — | — | EP | disclosed |
| EP-0569493-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1993-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11932683-B2 | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets | CXCR1, CXCR2, CXCR5 | P2RX7 1524/4885KDM4E 4734/4885MPO 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.