Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | BRD2 | P25440 | 2/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926377 | 0.88 | CYP1A2 (0.38) | BRD4BRD2BRD3CYP1A2CYP2C9 | |
| SCHEMBL10958183 | 0.83 | PTGS2 (0.48) | BRD4BRD2CYP1A2CYP2C9HTT | |
| SCHEMBL11427161 | 0.79 | KCNH2 (0.38) | BRD4BRD2BRD3CYP1A2CYP2C9 | |
| SCHEMBL11036464 | 0.74 | KCNH2 (0.44) | BRD4KCNH2HDAC1KDM4EALDH1A1 | |
| SCHEMBL10953599 | 0.74 | PTGS2 (0.43) | BRD4CYP1A2CYP2C9HTTKDM4E | |
| SCHEMBL10831572 | 0.74 | KDM4E (0.42) | KCNH2HDAC1HTTKDM4EALDH1A1 | |
| SCHEMBL10925293 | 0.74 | CYP3A4 (0.52) | BRD4BRD2BRD3CYP1A2CYP2C9 | |
| SCHEMBL11038024 | 0.73 | KDM4E (0.54) | BRD4KCNH2HDAC1KDM4EALDH1A1 | |
| SCHEMBL10924677 | 0.73 | BRD4 (0.43) | BRD4BRD2BRD3CYP1A2CYP2C9 | |
| SCHEMBL10957836 | 0.73 | CSF1R (0.42) | BRD4ALDH1A1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415568-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1983-11-15 | — | — | US | claimed |
| US-4336378-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | claimed |
| EP-0038298-B1 | ISOXAZOLYL INDOLAMINES | SANDOZ AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| US-4453001-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4415568-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4336378-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |
| EP-0038298-A1 | Isoxazolyl indolamines | SANDOZ AG (CH) | 1981-10-21 | — | — | EP | disclosed |