Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547097 | 1.00 | HSD17B3 (0.56) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL709614 | 0.80 | HSD17B3 (0.65) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL8900441 | 0.80 | HSD17B3 (0.65) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL699462 | 0.80 | HSD17B3 (0.65) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL31171234 | 0.80 | ENPP2 (0.56) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL11174939 | 0.80 | ENPP2 (0.56) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL11174940 | 0.80 | ENPP2 (0.56) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| SCHEMBL11047401 | 0.79 | APP (0.33) | HSD17B3ALDH1A1 | |
| SCHEMBL11047398 | 0.79 | APP (0.33) | HSD17B3ALDH1A1 | |
| SCHEMBL11464066 | 0.76 | HSD17B3 (0.61) | HSD17B3ALDH1A1PKMSLC6A19BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678591-A | Novel carboxamide compounds having MCH-antagonistic action, pharmaceutical preparations comprising said compounds and process for their preparation | BOEHRINGER INGELHEIM INT (DE) | 2005-10-05 | — | — | CN | disclosed |
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| US-4438277-A | Hydronaphthalene derivatives | SANKYO COMPANY, LIMITED (JP) | 1984-03-20 | — | — | US | disclosed |
| US-4401827-A | CARDIOTONIC AND ANTILIPEMIC AGENTS; BLOOD DISORDERS | SIGMA-TAU (IT) | 1983-08-30 | — | — | US | disclosed |
| US-4361515-A | Antihyperlipemic dihydro-ML-236B derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1982-11-30 | — | — | US | disclosed |
| US-4259350-A | PROTECTING DEGRADABLE ORGANIC MATERIAL FROM FUNGAL OR INSECT ATTACK | SANKYO COMPANY LIMITED (JP) | 1981-03-31 | — | — | US | disclosed |