Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15976429 | 0.91 | PLA2G2A (0.57) | PLA2G2APDE10ADHODHKDM4EALDH1A1 | |
| SCHEMBL140353 | 0.90 | PLA2G2A (0.64) | PLA2G2AALPLKDM4EALDH1A1CYP1A2 | |
| SCHEMBL110884 | 0.85 | PLA2G2A (0.59) | PLA2G2ADHODHKDM4EALDH1A1CYP1A2 | |
| SCHEMBL110393 | 0.85 | DHODH (0.52) | PLA2G2ADHODHKDM4EALDH1A1MEN1 | |
| SCHEMBL141016 | 0.81 | PLA2G2A (0.55) | PLA2G2AALPLKDM4EALDH1A1CYP1A2 | |
| SCHEMBL108830 | 0.81 | PLA2G2A (0.55) | PLA2G2AALPLKDM4EALDH1A1CYP1A2 | |
| SCHEMBL143039 | 0.80 | KDM4E (0.57) | PLA2G2ADHODHALPLKDM4EALDH1A1 | |
| SCHEMBL141017 | 0.77 | PLA2G2A (0.50) | PLA2G2AALPLKDM4ECYP1A2CYP2C9 | |
| SCHEMBL11004661 | 0.74 | NPC1 (0.55) | PLA2G2APTGS2ALPLKDM4EALDH1A1 | |
| SCHEMBL178679 | 0.72 | DYRK1A (0.45) | PLA2G2AKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815840-B2 | Carbazole and carboline kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | PLA2G2A 4509/4885PDE10A 1613/4885DHODH 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.