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Sugi Predict / Targets / PLA2G2A

PLA2G2A

Phospholipase A2, membrane associated · P14555 · PLA2G2A on Sugi Atlas →

148,042 patent compounds predicted against PLA2G2A, 56,238 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Varespladib Varespladib (SCHEMBL26726) 1.00 19/20
Varespladib Methyl Varespladib Methyl (SCHEMBL25678) 0.83 18/20
SCHEMBL110879 SCHEMBL110879 0.53 11/20
SCHEMBL26613 SCHEMBL26613 0.59 10/20
SCHEMBL25136 SCHEMBL25136 0.54 9/20
SCHEMBL213153 SCHEMBL213153 0.33 8/20
SCHEMBL110395 SCHEMBL110395 0.69 7/20
SCHEMBL140353 SCHEMBL140353 0.64 7/20
SCHEMBL108830 SCHEMBL108830 0.55 7/20
SCHEMBL141016 SCHEMBL141016 0.55 7/20
SCHEMBL144466 SCHEMBL144466 0.54 7/20
SCHEMBL110393 SCHEMBL110393 0.52 7/20
SCHEMBL141017 SCHEMBL141017 0.50 7/20
SCHEMBL140965 SCHEMBL140965 0.49 7/20
SCHEMBL145362 SCHEMBL145362 0.48 7/20
SCHEMBL214428 SCHEMBL214428 0.35 7/20
Flavone Flavone (SCHEMBL18879) 0.86 6/20
SCHEMBL110884 SCHEMBL110884 0.59 6/20
SCHEMBL141522 SCHEMBL141522 0.59 6/20
SCHEMBL141924 SCHEMBL141924 0.52 6/20

Clinical trials — most relevant to PLA2G2A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis PHASE3COMPLETED
Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy PHASE3COMPLETED
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study PHASE2/PHASE3RECRUITING
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN) PHASE1/PHASE2COMPLETED
DHA For The Treatment of Pediatric Concussion Related to Sports Injury PHASE1COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography PHASE1COMPLETED
Analysis of T- and B-Cell Subpopulations in Membranous Nephropathy nanCOMPLETED
Role of PLA2G1B During HIV Infection nanUNKNOWN
Effect of B-cell Depleting Therapies on PLA2R-specific B Cells in Patients With Membranous Nephropathy nanCOMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke nanCOMPLETED
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
PET Imaging of DHA Metabolism nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
An Outcome Analysis of Primary Membranous Nephropathy nanRECRUITING
Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy nanCOMPLETED
LDL-Apheresis for FSGS CardioRenal Outcomes nanCOMPLETED
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer nanCOMPLETED
Lp-PLA2 and Coronary Atherosclerosis in Humans nanCOMPLETED
MaxSimil and Vitamin K2: Determining Their Bioavailability nanCOMPLETED
Clinical Trial of PLA2R-IgG4 Detection Kit (Time-resolved Fluorescence Immunoassay) nanUNKNOWN
Autotaxin (ATX) as a Marker for Breast Cancer nanUNKNOWN
Molecular Markers of Human Sperm Function nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a PLA2G2A binder may also engage these)

ProteinNameSimilarity
P47711 — 1.000 P47711 →
P14423 — 0.997 P14423 →
P31482 — 0.996 P31482 →
Q56JZ2 — 0.995 Q56JZ2 →
A8CG90 — 0.995 A8CG90 →
Q9WVF6 — 0.994 Q9WVF6 →
P20474 — 0.994 P20474 →
PLA2G2D Group IID secretory phospholipase A2 0.993 landscape →
Q90W39 — 0.992 Q90W39 →
Q2YHJ7 — 0.991 Q2YHJ7 →
P24027 — 0.991 P24027 →
F5CPF1 — 0.991 F5CPF1 →
Q6EER4 — 0.991 Q6EER4 →
P49121 — 0.991 P49121 →
P0DJJ8 — 0.990 P0DJJ8 →
Q910A0 — 0.990 Q910A0 →
Q1RP78 — 0.990 Q1RP78 →
P0DKR5 — 0.990 P0DKR5 →
Q2YHJ2 — 0.989 Q2YHJ2 →
P0DJN7 — 0.989 P0DJN7 →
P20255 — 0.989 P20255 →
P00611 — 0.989 P00611 →
Q90ZZ9 — 0.989 Q90ZZ9 →
Q8JFG0 — 0.989 Q8JFG0 →
Q02471 — 0.989 Q02471 →
P31854 — 0.989 P31854 →
C7G1G6 — 0.989 C7G1G6 →
O42187 — 0.989 O42187 →
Q7ZTA8 — 0.989 Q7ZTA8 →
Q8AXW7 — 0.989 Q8AXW7 →