Hydrochloric Acid

Hydrochloric Acid

SCHEMBL11039728

COc1ccc(P(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1.COc1ccc(P(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1.COc1ccc(P(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1.[Cl-].[Cl-].[Ru+2]

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.48
CA1 P00915 3/20 0.58
CA2 P00918 3/20 0.58
CA7 P43166 2/20 0.58
CA9 Q16790 2/20 0.58
CA12 O43570 1/20 0.58
CA14 Q9ULX7 1/20 0.58
PKM P14618 1/20 0.46
TDP1 Q9NUW8 3/20 0.46
MAPK1 P28482 2/20 0.46
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
THRB P10828 1/20 0.44
RECQL P46063 1/20 0.44
RAB9A P51151 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21724600 0.95 CA1 (0.58) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL5427189 0.95 CA1 (0.58) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL10921791 0.95 CA1 (0.58) CA1CA2CA7CA9CA12
SCHEMBL15658842 0.95 CA1 (0.65) CA1CA2CA7CA9CA12
SCHEMBL50047 0.95 CA1 (0.65) CA1CA2CA7CA9CA12
SCHEMBL31328597 0.92 CA1 (0.61) CA1CA2CA7CA9CA12
SCHEMBL31378153 0.92 CA1 (0.61) CA1CA2CA7CA9CA12
SCHEMBL5713323 0.92 CA1 (0.61) CA1CA2CA7CA9CA12
Iodide SCHEMBL29883618 0.92 CA1 (0.61) CA1CA2CA7CA9CA12
Bromide SCHEMBL28409206 0.92 CA1 (0.61) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0046680-B1 IMPROVED CATALYTIC HYDROGENATION OF GLYCOLALDEHYDE TO PRODUCE ETHYLENE GLYCOL THE HALCON SD GROUP, INC. (US) 1984-06-20 EP disclosed
US-4321414-A IN THE PRESENCE OF A RUTHENIUM CATALYST THE HALCON SD GROUP, INC. (US) 1982-03-23 US disclosed
EP-0046680-A1 Improved catalytic hydrogenation of glycolaldehyde to produce ethylene glycol THE HALCON SD GROUP, INC. (US) 1982-03-03 EP disclosed