Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025105 | 0.95 | SLC29A1 (0.47) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11030078 | 0.94 | SLC29A1 (0.46) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11026053 | 0.93 | SLC29A1 (0.50) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11032117 | 0.93 | SLC29A1 (0.52) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11028323 | 0.92 | SLC29A1 (0.45) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11043039 | 0.91 | SLC29A1 (0.47) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11023685 | 0.90 | PDE4A (0.45) | SLC29A1POLBHTTPDE4APDE4B | |
| SCHEMBL11042976 | 0.89 | SLC29A1 (0.49) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL2459746 | 0.89 | PDE4A (0.55) | SLC29A1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL11048887 | 0.88 | SLC29A1 (0.42) | SLC29A1POLBHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |