Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11048920 | 0.94 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11062725 | 0.94 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL2459746 | 0.91 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11041201 | 0.90 | SLC29A1 (0.52) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11048555 | 0.87 | ACHE (0.47) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11028726 | 0.87 | OGA (0.53) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11029770 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL10660880 | 0.85 | NPSR1 (0.43) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL11025105 | 0.85 | SLC29A1 (0.47) | PDE4APDE4BPDE4CPDE4DSLC29A1 | |
| SCHEMBL11029641 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DSLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |