Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.37 |
| ▸ | DRD5 | P21918 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913238 | 0.81 | GAA (0.56) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL11129395 | 0.75 | GAA (0.49) | GAACYP11B1CYP11B2BCL2MAOA | |
| Hydrochloric Acid SCHEMBL11039966 | 0.74 | GAA (0.48) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL11044464 | 0.72 | GAA (0.68) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL322514 | 0.71 | TRPA1 (0.39) | GAACYP11B1CYP11B2CYP1A2CA1 | |
| SCHEMBL1091043 | 0.67 | CA12 (0.39) | CYP1A2CA1CA2 | |
| SCHEMBL4133299 | 0.67 | GAA (0.50) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL31463289 | 0.67 | GAA (0.50) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL10232028 | 0.67 | GAA (0.57) | GAACYP11B1CYP11B2BCL2MAOA | |
| SCHEMBL14181700 | 0.66 | CYP11B1 (0.54) | GAACYP11B1CYP11B2BCL2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116444-A2 | Improvements in or relating to benzazepine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | disclosed |