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TRPA1

Transient receptor potential cation channel subfamily A member 1 · O75762 · TRPA1 on Sugi Atlas →

193,703 patent compounds predicted against TRPA1, 103,946 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2932 SCHEMBL2932 0.64 15/20
SCHEMBL10435 SCHEMBL10435 0.64 15/20
SCHEMBL14646 SCHEMBL14646 0.64 15/20
SCHEMBL3256 SCHEMBL3256 1.00 14/20
SCHEMBL3120 SCHEMBL3120 0.71 13/20
SCHEMBL11227 SCHEMBL11227 0.71 13/20
SCHEMBL2133 SCHEMBL2133 0.64 13/20
SCHEMBL2134 SCHEMBL2134 0.64 13/20
SCHEMBL3737 SCHEMBL3737 0.64 13/20
SCHEMBL10059 SCHEMBL10059 0.64 13/20
SCHEMBL11264 SCHEMBL11264 0.64 13/20
SCHEMBL14670 SCHEMBL14670 0.64 13/20
SCHEMBL10825 SCHEMBL10825 0.67 11/20
SCHEMBL11550 SCHEMBL11550 0.64 11/20
SCHEMBL10438 SCHEMBL10438 0.53 10/20
SCHEMBL14645 SCHEMBL14645 0.53 10/20
SCHEMBL3580 SCHEMBL3580 0.74 9/20
SCHEMBL10827 SCHEMBL10827 0.74 9/20
SCHEMBL14599 SCHEMBL14599 0.74 9/20
SCHEMBL12109 SCHEMBL12109 0.52 9/20

Clinical trials — most relevant to TRPA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
Botulinum Toxin Injections for Oral Neuropathic Pain PHASE3COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions PHASE2RECRUITING
Use Of SB-705498 In The Acute Treatment Of Migraine PHASE2COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer PHASE1RECRUITING
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers nanRECRUITING
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin nanCOMPLETED
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus nanCOMPLETED
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRPA1 binder may also engage these)

ProteinNameSimilarity
Q8BLA8 — 1.000 Q8BLA8 →
Q6RI86 — 1.000 Q6RI86 →
Q80YE7 — 0.985 Q80YE7 →
DAPK1 Death-associated protein kinase 1 0.985 landscape →
Q9BGT9 — 0.984 Q9BGT9 →
Q18297 — 0.984 Q18297 →
TRPC1 Short transient receptor potential channel 1 0.983 landscape →
Q8VHS6 — 0.983 Q8VHS6 →
Q61056 — 0.983 Q61056 →
Q9EQG6 — 0.981 Q9EQG6 →
Q8HXA6 — 0.981 Q8HXA6 →
Q7T163 — 0.981 Q7T163 →
Q9M8S6 — 0.981 Q9M8S6 →
Q9WV71 — 0.981 Q9WV71 →
P69744 — 0.980 P69744 →
Q8WXK1 — 0.980 Q8WXK1 →
Q94A76 — 0.980 Q94A76 →
Q9W0Y6 — 0.980 Q9W0Y6 →
Q80ZJ6 — 0.980 Q80ZJ6 →
Q38998 — 0.980 Q38998 →
Q4R3S3 — 0.980 Q4R3S3 →
Q704Y3 — 0.980 Q704Y3 →
Q9JIP0 — 0.979 Q9JIP0 →
Q91ZU0 — 0.979 Q91ZU0 →
A6NHY2 — 0.979 A6NHY2 →
Q5RAG3 — 0.979 Q5RAG3 →
Q9XSM3 — 0.979 Q9XSM3 →
Q7Z7L7 — 0.978 Q7Z7L7 →
Q9ULH0 — 0.978 Q9ULH0 →
Q9QX01 — 0.978 Q9QX01 →