Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | ADK | P55263 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.39 |
| ▸ | TYMS | P04818 | 2/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043656 | 0.83 | CA2 (0.43) | IDO1CA2PTGER3TYMSKDM4E | |
| SCHEMBL11039068 | 0.82 | CA2 (0.54) | IDO1CA2GSK3BADKKDM4E | |
| SCHEMBL11040694 | 0.74 | CA2 (0.47) | CA2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11040723 | 0.73 | CA2 (0.64) | CA2KDM4E | |
| SCHEMBL11041002 | 0.72 | CA2 (0.58) | CA2KDM4EALDH1A1LMNA | |
| SCHEMBL17258148 | 0.72 | IDO1 (1.00) | IDO1LMNAMAPTCYP2C19ABCG2 | |
| SCHEMBL11047713 | 0.71 | CA2 (0.49) | CA2PTGER3CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL10545336 | 0.71 | CA2 (0.42) | CA2CASP3BLMSENP8SENP7 | |
| SCHEMBL11041960 | 0.70 | CA2 (0.60) | CA2 | |
| SCHEMBL11040315 | 0.69 | CA2 (0.67) | CA2GSK3BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |