Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032173 | 0.90 | NPC1 (0.81) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL4262518 | 0.82 | NPC1 (0.74) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL19043207 | 0.82 | NPC1 (0.74) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL9118933 | 0.81 | MAPT (0.66) | NPC1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL6317361 | 0.81 | NPC1 (0.72) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL7627400 | 0.81 | NPC1 (0.72) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL27796196 | 0.81 | NPC1 (0.72) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL9657455 | 0.81 | NPC1 (0.83) | NPC1ALDH1A1PARP10L3MBTL1LMNA | |
| SCHEMBL19043463 | 0.81 | NPC1 (0.83) | NPC1L3MBTL1 | |
| SCHEMBL3027529 | 0.80 | HPGD (0.52) | NPC1ALDH1A1L3MBTL1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |