Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | MMP1 | P03956 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16552644 | 0.88 | MMP1 (0.76) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL27434152 | 0.86 | HDAC8 (0.68) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL3023192 | 0.84 | HDAC3 (0.66) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL4082864 | 0.84 | PDE4B (0.86) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL3171960 | 0.84 | PDE4B (0.79) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL705208 | 0.82 | MAPT (0.68) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL2633872 | 0.82 | MAPT (0.68) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL11041909 | 0.81 | NPC1 (0.74) | MAPTNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL515747 | 0.81 | MAPT (0.77) | MAPTPDE4BNPC1RAB9AMMP1 | |
| SCHEMBL503582 | 0.81 | PDE4B (0.80) | MAPTPDE4BNPC1RAB9AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037510-C | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1998-02-25 | — | — | CN | claimed |
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | claimed |
| CN-1088576-A | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1994-06-29 | — | — | CN | claimed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | claimed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | claimed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-3979444-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, HYPOTENSIVES | THE UPJOHN COMPANY (US) | 1976-09-07 | — | — | US | claimed |
| CN-115872825-A | Preparation method of 1,3-disubstituted allene compound based on gold carbene catalytic system at room temperature | 中国科学院上海有机化学研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-1040876-C | New derivatives of erythromycin, their preparation process, their use as medicaments | ROUSSEL UCLAF (FR) | 1998-11-25 | — | — | CN | disclosed |
| CN-1037510-C | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1998-02-25 | — | — | CN | disclosed |
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | disclosed |
| CN-1090581-A | The preparation method of the novel derivative of erythromycin and they and as the application of medicine | ROUSSEL UCLAF (FR) | 1994-08-10 | — | — | CN | disclosed |
| CN-1088576-A | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1994-06-29 | — | — | CN | disclosed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-4025558-A | SPIRO(CYCLOHEXANE-1,1*(2'H)-NAPHTHALENE); BENZOSPIRAN DERIVATIVES; CNS DEPRESSANTS, LOWERS BLOOD PRESSURE | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-4010201-A | AMINOBENZOSPIRANS, CENTRAL NERVOUS SYSTEM DEPRESSANT, HYPOTENSIVE | THE UPJOHN COMPANY (US) | 1977-03-01 | — | — | US | disclosed |
| US-3979444-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, HYPOTENSIVES | THE UPJOHN COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3961066-A | ANALGESICS, ANTITUSSIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-06-01 | — | — | US | disclosed |
| US-3953425-A | Azepine indanyl and tetralin butyrophenones | THE UPJOHN COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3932425-A | CNS DEPRESSANT, BLOOD PRESSURE LOWERING | THE UPJOHN COMPANY (US) | 1976-01-13 | — | — | US | disclosed |