Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023195 | 0.98 | TP53 (0.55) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL17937297 | 0.86 | PARP10 (0.60) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL27663748 | 0.84 | HSD17B3 (0.60) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL19043416 | 0.84 | PARP10 (0.62) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL13492946 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL27434152 | 0.83 | HDAC8 (0.68) | MAPTALDH1A1KMT2AHDAC8HDAC1 | |
| SCHEMBL7925884 | 0.83 | STS (0.59) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL19043534 | 0.82 | ALDH1A1 (0.51) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL7625396 | 0.82 | KMT2A (0.45) | MAPTALDH1A1TP53THRBHTT | |
| SCHEMBL7627643 | 0.82 | KMT2A (0.45) | MAPTALDH1A1TP53THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |