Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037795 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11043494 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11040051 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11038899 | 0.78 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11040888 | 0.78 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11041255 | 0.77 | PPARG (0.53) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11039043 | 0.76 | PPARG (0.52) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL10798526 | 0.75 | PPARG (0.54) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL10800272 | 0.75 | PPARG (0.54) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL11037265 | 0.75 | MAPT (0.61) | ALDH1A1MAPTKDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | claimed |
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |