Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.72 |
| ▸ | PPARD | Q03181 | 3/20 | 0.72 |
| ▸ | PPARA | Q07869 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.69 |
| ▸ | CYSLTR2 | Q9NS75 | 13/20 | 0.64 |
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043538 | 1.00 | PPARG (0.72) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL5032476 | 0.98 | GRM2 (0.72) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL5032472 | 0.98 | GRM2 (0.72) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11041707 | 0.92 | PPARG (0.62) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11041702 | 0.92 | PPARG (0.62) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL25203622 | 0.89 | GRM2 (0.66) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11047150 | 0.88 | CYSLTR2 (0.71) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL11047154 | 0.88 | CYSLTR2 (0.71) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL25200569 | 0.87 | GRM2 (0.68) | PPARGPPARDPPARALMNACYP1A2 | |
| SCHEMBL10807112 | 0.87 | CYSLTR2 (0.58) | PPARGPPARDPPARALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028063-B1 | PHENOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-06-13 | — | — | EP | disclosed |
| EP-0028063-A1 | Phenol derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1981-05-06 | — | — | EP | disclosed |