SCHEMBL1104414

SCHEMBL1104414

Sc1nnc(-c2ccncc2)n1-c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 6/20 0.59
KDM4E B2RXH2 4/20 0.59
ALDH1A1 P00352 4/20 0.57
AVPR1A P37288 1/20 0.49
MAPK10 P53779 3/20 0.47
MAPK9 P45984 2/20 0.47
PTK2 Q05397 4/20 0.46
HDAC2 Q92769 3/20 0.46
HDAC3 O15379 2/20 0.46
HDAC1 Q13547 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
HDAC6 Q9UBN7 2/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
MAPT P10636 2/20 0.44
TSHR P16473 1/20 0.44
POLB P06746 1/20 0.44
RECQL P46063 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1104395 0.89 AVPR1A (0.59) HSD17B10KDM4EALDH1A1AVPR1ATSHR
SCHEMBL11511067 0.89 AVPR1A (0.59) HSD17B10KDM4EALDH1A1AVPR1ATSHR
SCHEMBL20869675 0.85 HSD17B10 (0.58) HSD17B10KDM4EALDH1A1MAPK10MAPK9
SCHEMBL11965040 0.84 HSD17B10 (0.69) HSD17B10KDM4EALDH1A1AVPR1AMAPK10
SCHEMBL6408173 0.83 CYP3A4 (0.53) HSD17B10KDM4EALDH1A1MAPK10MAPK9
SCHEMBL11919915 0.83 HTT (0.53) HSD17B10KDM4EALDH1A1MAPK10MAPK9
SCHEMBL13048284 0.83 HSD17B10 (0.43) HSD17B10KDM4EALDH1A1MAPK10MAPK9
SCHEMBL15708921 0.83 ALDH1A1 (0.56) HSD17B10KDM4EALDH1A1MAPK10MAPK9
SCHEMBL1104404 0.83 AVPR1A (0.57) HSD17B10KDM4EALDH1A1AVPR1AMAPT
SCHEMBL10432252 0.82 ALDH1A1 (0.55) HSD17B10KDM4EALDH1A1AVPR1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2141206-B1 Novel compound, polymerizable composition, color filter and production method thereof, solid-state imaging device, and planographic printing plate precursor FUJIFILM CORP (JP) 2014-12-03 EP disclosed
US-8846277-B2 Compound, polymerizable composition, color filter, and method of producing the same, solid-state imaging device, and planographic printing plate precursor FUJIFILM CORPORATION (JP) 2014-09-30 US disclosed
US-8846277-B2 Compound, polymerizable composition, color filter, and method of producing the same, solid-state imaging device, and planographic printing plate precursor FUJIFILM CORPORATION (JP) 2014-09-30 US disclosed
US-8728686-B2 Photosensitive compositions, curable compositions, novel compounds, photopolymerizable compositions, color filters, and planographic printing plate precursors FUJIFILM CORPORATION (JP) 2014-05-20 US disclosed
US-8728686-B2 Photosensitive compositions, curable compositions, novel compounds, photopolymerizable compositions, color filters, and planographic printing plate precursors FUJIFILM CORPORATION (JP) 2014-05-20 US disclosed
US-8703366-B2 2014-04-22 US disclosed
US-8703366-B2 2014-04-22 US disclosed
US-20120295204-A1 PROCESSING METHOD OF LITHOGRAPHIC PRINTING PLATE PREURSOR FUJIFILM CORPORATION (JP) 2012-11-22 US disclosed
US-20120295204-A1 PROCESSING METHOD OF LITHOGRAPHIC PRINTING PLATE PREURSOR FUJIFILM CORPORATION (JP) 2012-11-22 US disclosed
US-8257913-B2 Processing method of lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2012-09-04 US disclosed
US-20070207411-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2007-09-06 US disclosed
US-20070184387-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2007-08-09 US disclosed
US-20070184387-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2007-08-09 US disclosed
US-20070128550-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2007-06-07 US disclosed
US-20070128550-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2007-06-07 US disclosed
US-20070020563-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJI PHOTO FILM CO., LTD. 2007-01-25 US disclosed
US-20070020563-A1 Method for preparation of lithographic printing plate and lithographic printing plate precursor FUJI PHOTO FILM CO., LTD. 2007-01-25 US disclosed
US-20050288347-A1 Certain triazole-based compounds, compositions, and uses thereof AGRIUS GROUP, LLC. 2005-12-29 US disclosed
EP-0359505-A1 Dopamine-beta hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1990-03-21 EP disclosed
US-4481360-A 4H-1,2,4-Triazol-3-yl compounds THE UPJOHN COMPANY (US) 1984-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050288347-A1 Certain triazole-based compounds, compositions, and uses thereof ABCG2, ATP5ME, DNTT HSD17B10 1270/4885KDM4E 3676/4885ALDH1A1 720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.