SCHEMBL11045006

SCHEMBL11045006

O=C(NC1CC(=O)N(C(=O)OCC(Cl)(Cl)Cl)C1=O)OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CTSL P07711 3/20 0.43
CTSB P07858 3/20 0.43
PREP P48147 2/20 0.43
NAAA Q02083 1/20 0.43
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
CASP1 P29466 2/20 0.42
PARP1 P09874 1/20 0.41
CASP3 P42574 2/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11048349 0.87 GAA (0.51) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL26317923 0.83 KMT2A (0.45) CTSLCTSBPREPGAA
SCHEMBL3932072 0.78 SMN1; SMN2 (0.59) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL3932081 0.78 SMN1; SMN2 (0.59) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL6216047 0.78 SMN1; SMN2 (0.59) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL12345121 0.77 NAAA (0.50) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL13017770 0.77 NAAA (0.50) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL26317914 0.77 KMT2A (0.43) ALDH1A1
SCHEMBL13495794 0.77 NAAA (0.47) CTSLCTSBPREPNAAAALDH1A1
SCHEMBL8342642 0.76 GAA (0.63) PREPNAAAALDH1A1GAAPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4465844-A PEPTIDE, GERMICIDE, DISINFECTANT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-08-14 US disclosed
US-4436918-A FROM A 2,5-DIOXOPYRROLIDINE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-03-13 US disclosed