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Sugi Predict / Targets / NAAA

NAAA

N-acylethanolamine-hydrolyzing acid amidase · Q02083 · NAAA on Sugi Atlas →

149,918 patent compounds predicted against NAAA, 81,718 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Phenylhexyl Isothiocyanate Phenylhexyl Isothiocyanate (SCHEMBL7809) 1.00 8/20
SCHEMBL106183 SCHEMBL106183 0.54 5/20
SCHEMBL97849 SCHEMBL97849 0.44 5/20
SCHEMBL54245 SCHEMBL54245 0.59 4/20
Benzyl Isothiocyanate Benzyl Isothiocyanate (SCHEMBL44145) 0.53 4/20
Sulforaphane Sulforaphane (SCHEMBL105202) 0.50 4/20
Sulforaphane Sulforaphane (SCHEMBL105203) 0.50 4/20
SCHEMBL58823 SCHEMBL58823 0.44 4/20
SCHEMBL97586 SCHEMBL97586 0.44 4/20
SCHEMBL57600 SCHEMBL57600 0.43 4/20
SCHEMBL96537 SCHEMBL96537 0.42 4/20
SCHEMBL97909 SCHEMBL97909 0.42 4/20
SCHEMBL59225 SCHEMBL59225 0.42 4/20
SCHEMBL97499 SCHEMBL97499 0.36 4/20
SCHEMBL97500 SCHEMBL97500 0.36 4/20
SCHEMBL88365 SCHEMBL88365 0.71 3/20
SCHEMBL98283 SCHEMBL98283 0.48 3/20
SCHEMBL57427 SCHEMBL57427 0.48 3/20
SCHEMBL96961 SCHEMBL96961 0.47 3/20
SCHEMBL97331 SCHEMBL97331 0.47 3/20

Clinical trials — most relevant to NAAA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment Strategies in CHS PHASE4COMPLETED
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Lithium and Acetate for Canavan Disease PHASE2WITHDRAWN
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty PHASE1/PHASE2NOT_YET_RECRUITING
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions PHASE2RECRUITING
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS) PHASE1/PHASE2COMPLETED
Safety and Efficacy of Repeat Administration of Ad/PNP and Fludarabine Phosphate in Patients With Local Head/Neck Cancer PHASE1/PHASE2COMPLETED
GTA-Glyceryltriacetate for Canavan Disease PHASE1UNKNOWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Bisnorcymserine in Healthy Adult Volunteers PHASE1COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers nanCOMPLETED
Oatmeal Effect on N-acyl-phosphatidylethanolamines nanCOMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients nanCOMPLETED
Psychological and Biological Markers of Refractory Migraine nanUNKNOWN
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte nanCOMPLETED
Treatment Response in Schizophrenia: Bridging Imaging and Postmortem Studies nanCOMPLETED
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
Registry Gangliosidoses nanUNKNOWN
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia nanUNKNOWN
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML) nanWITHDRAWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Human Requirements for the Nutrient Choline nanCOMPLETED
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
The Effect of Palmitylethanolamide on Central and Peripheral Sensitization After Heat-induced Hyperalgesia nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NAAA binder may also engage these)

ProteinNameSimilarity
Q9D7V9 — 1.000 Q9D7V9 →
G1T7U7 — 1.000 G1T7U7 →
H0VCJ6 — 1.000 H0VCJ6 →
Q5KTC7 — 0.997 Q5KTC7 →
Q9WV54 — 0.982 Q9WV54 →
Q4QQW8 — 0.981 Q4QQW8 →
A0A0P6JG37 — 0.981 A0A0P6JG37 →
Q5U2V4 — 0.980 Q5U2V4 →
Q2KIY5 — 0.979 Q2KIY5 →
Q8VCI0 — 0.978 Q8VCI0 →
ASAH1 Acid ceramidase 0.978 landscape →
Q6P1J0 — 0.977 Q6P1J0 →
Q6P4A8 — 0.977 Q6P4A8 →
Q17QB3 — 0.977 Q17QB3 →
A5A6P2 — 0.976 A5A6P2 →
Q3TCN2 — 0.976 Q3TCN2 →
A0A383ZFX3 — 0.974 A0A383ZFX3 →
Q9GL30 — 0.974 Q9GL30 →
Q7Z4N8 — 0.973 Q7Z4N8 →
Q9GUI1 — 0.973 Q9GUI1 →
Q5R5N6 — 0.973 Q5R5N6 →
Q60HH4 — 0.973 Q60HH4 →
Q69ZQ1 — 0.972 Q69ZQ1 →
O97524 — 0.971 O97524 →
Q9ES45 — 0.970 Q9ES45 →
Q9UK23 — 0.970 Q9UK23 →
O77695 — 0.970 O77695 →
Q9W369 — 0.970 Q9W369 →
Q8NHP8 — 0.970 Q8NHP8 →
Q95KC9 — 0.969 Q95KC9 →