Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.73 |
| ▸ | PGR | P06401 | 8/20 | 0.73 |
| ▸ | USP2 | O75604 | 7/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 6/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.73 |
| ▸ | CNR1 | P21554 | 3/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054207 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11045196 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL19681910 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL19393185 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11054196 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL23892577 | 1.00 | NR3C1 (0.73) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11588122 | 0.93 | NR3C1 (0.63) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11588127 | 0.93 | NR3C1 (0.63) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11788733 | 0.92 | NR3C1 (0.70) | NR3C1PGRUSP2HIF1ALMNA | |
| SCHEMBL11788721 | 0.92 | NR3C1 (0.70) | NR3C1PGRUSP2HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427591-A | TOPICAL ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1984-01-24 | — | — | US | disclosed |
| US-4336200-A | 17α-Acyloxy-5β-corticoids | THE UPJOHN COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4318853-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4124707-A | 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1978-11-07 | — | — | US | disclosed |