Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 5/20 | 0.79 |
| ▸ | PGR | P06401 | 5/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.79 |
| ▸ | AR | P10275 | 4/20 | 0.79 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.79 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.79 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | ESR1 | P03372 | 3/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.63 |
| ▸ | SHBG | P04278 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10821091 | 0.89 | ABCB11 (0.63) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL1232662 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL11321479 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL14074495 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL14360522 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL37530 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| Norethindrone Acetate SCHEMBL14577826 | 0.89 | CYP3A4 (1.00) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL11291553 | 0.89 | CYP3A4 (0.85) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL9473282 | 0.88 | CYP3A4 (0.84) | CYP3A4ABCB11PGRCYP2C19AR | |
| SCHEMBL8853605 | 0.87 | CYP3A4 (0.82) | CYP3A4ABCB11PGRCYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063368-B1 | PROCESS FOR THE PREPARATION OF PREGN-4-ENE-3,20-DIONE DERIVATIVES AND 17-ALPHA-ETHYNYL-17-BETA-TRIFLUOROACETOXY-GON-4-ENE-3-ONE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE LATTER COMPOUNDS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1984-07-25 | — | — | EP | claimed |
| US-4482494-A | Process for preparing 17α-hydroxy-pregn-4-en-3,20-dione | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1984-11-13 | — | — | US | disclosed |
| US-4368160-A | Process for preparing 17α-hydroxy-pregn-4-en-3,20-dione derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1983-01-11 | — | — | US | disclosed |