Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.82 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.82 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.82 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | ATM | Q13315 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104743 | 0.94 | ADORA2A (0.72) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL29354597 | 0.93 | ADORA2A (0.83) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL8095238 | 0.93 | ADORA2A (0.83) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL10089214 | 0.92 | ADORA2A (0.88) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL13259762 | 0.92 | ADORA2A (0.88) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL8923545 | 0.92 | ADORA2A (0.88) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL8925079 | 0.92 | ADORA2A (0.88) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL1104744 | 0.90 | ADORA2A (0.76) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| Cgs-21680 SCHEMBL24178317 | 0.90 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL20615307 | 0.90 | ADORA2A (0.88) | ADORA2AADORA3ADORA1ADORA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153781-B2 | Dendrimer conjugates of agonists and antagonists of the GPCR superfamily | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090012035-A1 | DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPA (US) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012035-A1 | DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY | ADORA1, ADORA2A, ADORA3 | ADORA2A 2/4885ADORA3 3/4885ADORA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.