Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10958165 | 0.87 | AKR1B1 (0.37) | AKR1B1AKR1A1 | |
| SCHEMBL10957429 | 0.86 | AKR1B1 (0.53) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL11048812 | 0.84 | PTGDR2 (0.50) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL4252944 | 0.84 | AKR1B1 (0.42) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10956203 | 0.83 | AKR1B1 (0.51) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL11007731 | 0.83 | AKR1B1 (0.41) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL11003981 | 0.76 | GFER (0.43) | AKR1B1 | |
| SCHEMBL10844292 | 0.75 | CHRM5 (0.51) | AKR1B1 | |
| SCHEMBL10365052 | 0.74 | CHRM5 (0.55) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL4263802 | 0.73 | AKR1B1 (0.43) | AKR1B1AKR1A1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4490381-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS, ALSO ALDOSE REDUCTASE INHIBIIOTRS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-12-25 | — | — | US | disclosed |
| EP-0028906-B1 | 1'-SUBSTITUTED-SPIRO(IMIDAZOLIDINE-4,3'-INDOLINE)-2,2',5-TRIONES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-03 | — | — | EP | disclosed |
| EP-0028906-A1 | 1'-Substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-20 | — | — | EP | disclosed |