Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10957429 | 0.90 | AKR1B1 (0.53) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL4252944 | 0.88 | AKR1B1 (0.42) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10956203 | 0.86 | AKR1B1 (0.51) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL11007731 | 0.86 | AKR1B1 (0.41) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL11047602 | 0.84 | AKR1B1 (0.40) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10844292 | 0.82 | CHRM5 (0.51) | AKR1B1 | |
| SCHEMBL10365052 | 0.81 | CHRM5 (0.55) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL4255735 | 0.78 | TP53 (0.52) | PTGDR2AKR1B1AKR1A1 | |
| SCHEMBL11045654 | 0.77 | TP53 (0.54) | AKR1B1AKR1A1 | |
| SCHEMBL4254345 | 0.77 | PTGDR2 (0.42) | PTGDR2AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028906-B1 | 1'-SUBSTITUTED-SPIRO(IMIDAZOLIDINE-4,3'-INDOLINE)-2,2',5-TRIONES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-03 | — | — | EP | claimed |
| EP-0028906-A1 | 1'-Substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-20 | — | — | EP | claimed |
| US-4490381-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS, ALSO ALDOSE REDUCTASE INHIBIIOTRS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-12-25 | — | — | US | disclosed |
| EP-0028906-B1 | 1'-SUBSTITUTED-SPIRO(IMIDAZOLIDINE-4,3'-INDOLINE)-2,2',5-TRIONES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-03 | — | — | EP | disclosed |
| US-4386100-A | COMPLICATIONS OF DIABETES OR GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-05-31 | — | — | US | disclosed |
| EP-0066378-A1 | Pharmaceutical spiro-hydantoin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-08 | — | — | EP | disclosed |
| EP-0028906-A1 | 1'-Substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-20 | — | — | EP | disclosed |