Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flavane SCHEMBL27595228 | 0.86 | ESR1 (0.51) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL14394530 | 0.86 | ESR1 (0.51) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL27889134 | 0.86 | ESR1 (0.51) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL123287 | 0.86 | ESR1 (0.51) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL29478071 | 0.86 | ESR1 (0.51) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL28405195 | 0.84 | ESR1 (0.50) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL28823768 | 0.84 | ESR1 (0.50) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL28529260 | 0.84 | ESR1 (0.50) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL28787244 | 0.84 | ESR1 (0.50) | ESR1ESR2KDM4EHTR1AADRA2A | |
| Flavane SCHEMBL28394714 | 0.84 | ESR1 (0.50) | ESR1ESR2KDM4EHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461907-A | Amino-substituted flavans useful as anti-viral agents | BURROUGHS WELLCOME CO. | 1984-07-24 | — | — | US | disclosed |
| EP-0004579-B1 | FLAVANS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-08-18 | — | — | EP | disclosed |
| EP-0051061-A2 | Novel intermediates and process for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-05-05 | — | — | EP | disclosed |
| EP-0004579-A1 | Flavans, process for their preparation and pharmaceutical compositions containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-10-17 | — | — | EP | disclosed |