Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 12/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053818 | 0.80 | AGTR2 (0.54) | AGTR2ACE | |
| SCHEMBL11053812 | 0.80 | AGTR2 (0.54) | AGTR2ACE | |
| SCHEMBL16350185 | 0.80 | ABCB1 (0.51) | AGTR2ABCB1TACR3 | |
| SCHEMBL6183348 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL21409001 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL1373084 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL13687997 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL7285245 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL9542940 | 0.79 | NR1H2 (0.48) | AGTR2ACE | |
| SCHEMBL6183345 | 0.79 | NR1H2 (0.48) | AGTR2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |