Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103092 | 0.82 | POLB (0.66) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7521559 | 0.81 | POLB (0.64) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9849499 | 0.79 | POLB (0.62) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2531203 | 0.79 | POLB (0.62) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28026104 | 0.77 | POLB (0.59) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL25245924 | 0.76 | NT5E (0.58) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL10263305 | 0.76 | KDM4E (0.73) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL30460713 | 0.76 | NT5E (0.58) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL875697 | 0.74 | KDM4E (0.58) | POLBKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3111650 | 0.73 | POLB (0.71) | POLBKDM4EALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035820-B1 | NOVEL QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHOD FOR THE PREPARATION OF THESE COMPOUNDS | ACF CHEMIEFARMA NV (NL) | 1984-10-10 | — | — | EP | disclosed |
| US-4472403-A | Quinoline derivatives and pharmaceutical compositions and methods for treating cardiovascular disease with such compounds | A.C.F. CHEMIEFARMA N.V. (NL) | 1984-09-18 | — | — | US | disclosed |
| US-4443453-A | HYPOTENSIVE, VASODILATION, ANTIARRHYTHMIA, ANTICOAGULANTS | ACF CHEMIEFARMA N.V. (NL) | 1984-04-17 | — | — | US | disclosed |
| US-4442106-A | HYPOTENSIVE, ANTIARRHYTHMIA | ACF CHEMIEFARMA N.V. (NL) | 1984-04-10 | — | — | US | disclosed |
| EP-0035820-A2 | Novel quinoline derivatives, pharmaceutical compositions containing such compounds, and method for the preparation of these compounds | ACF CHEMIEFARMA NV (NL) | 1981-09-16 | — | — | EP | disclosed |
| EP-0030044-A1 | Quinoline derivatives, processes for their preparation, their use, pharmaceutical compositions containing them and a method for the preparation of these pharmaceutical compositions | ACF CHEMIEFARMA NV (NL) | 1981-06-10 | — | — | EP | disclosed |