Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5433758 | 0.86 | KDM4E (0.56) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL6104751 | 0.84 | KDM4E (0.50) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8103092 | 0.82 | POLB (0.66) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL25912335 | 0.81 | DHODH (0.48) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7521559 | 0.81 | POLB (0.64) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL2531203 | 0.79 | POLB (0.62) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11049820 | 0.79 | POLB (0.62) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL15798322 | 0.79 | KDM4E (0.73) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL5798135 | 0.79 | KDM4E (0.49) | POLBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL29845288 | 0.78 | KMT2A (0.56) | POLBKDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |
| US-3994733-A | CYANINE DYES, A BENZOTHIAZOLE, OR BENZOTHIAZOLONE, OR NAPHTHOTHIAZOLE, OR NAPHTHOTHIAZOLONE, OR A QUINOLONE | FUJI PHOTO FILM CO., LTD. (JA) | 1976-11-30 | — | — | US | disclosed |