Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050905 | 0.89 | NPC1 (0.51) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11258056 | 0.88 | MEN1 (0.47) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11053819 | 0.86 | KMT2A (0.46) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11051067 | 0.86 | HTT (0.43) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11055583 | 0.85 | MAPT (0.47) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11053662 | 0.84 | NPC1 (0.49) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11048661 | 0.84 | MAPK1 (0.52) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11056245 | 0.84 | NPC1 (0.46) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL11051039 | 0.83 | HTT (0.49) | ALDH1A1NPC1RAB9AMAPK1MEN1 | |
| SCHEMBL11053893 | 0.82 | RAB9A (0.43) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |