SCHEMBL1105073

SCHEMBL1105073

Cc1cc(C)c([SiH3])c(C)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 9/20 0.45
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
TP53 P04637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SELL P14151 1/20 0.33
SELP P16109 1/20 0.33
SELE P16581 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
MMP8 P22894 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4464620 0.97 RAPGEF4 (0.43) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL27928644 0.76 IDO1 (0.38) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL27943136 0.73 TSHR (0.41) RAPGEF4ALDH1A1TSHRTP53HSD17B10
SCHEMBL27943189 0.73 CYP3A4 (0.52) ALDH1A1GAATDP1CA1CA2
SCHEMBL28040819 0.71 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL1551822 0.69 RAPGEF4 (0.59) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL28951 0.69 RAPGEF4 (0.59) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL317299 0.69 RAPGEF4 (0.50) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL14237002 0.67 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL8380464 0.67 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4ELMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114920768-A Preparation method and application of tert-butyl substituted dihydrosilane and chiral silane 深圳湾实验室 2022-08-19 CN claimed
CN-117279981-A Method for producing polysiloxazanes and for producing amino-functional polyorganosiloxanes using same 美国陶氏有机硅公司 2023-12-22 CN disclosed
CN-114874244-B Preparation method of aryl borate or alkyl borate compound 中国科学院兰州化学物理研究所 2023-12-01 CN disclosed
CN-114920768-A Preparation method and application of tert-butyl substituted dihydrosilane and chiral silane 深圳湾实验室 2022-08-19 CN disclosed
CN-114874244-A Preparation method of arylboronic acid ester or alkyl boronate compound 中国科学院兰州化学物理研究所 2022-08-09 CN disclosed
CN-114630857-A Method for producing polyepoxysazanes and for producing aminofunctional polyorganosiloxanes using polyepoxysazanes 美国陶氏有机硅公司 2022-06-14 CN disclosed
CN-109311918-B Ligand compound, transition metal compound and catalyst composition comprising same LG化学株式会社 2021-07-27 CN disclosed
CN-109311918-A Ligand compound, transition metal compound and catalyst composition comprising same LG化学株式会社 2019-02-05 CN disclosed
US-9458185-B2 First row metal-based catalysts for hydosilylation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-10-04 US disclosed
US-9458185-B2 First row metal-based catalysts for hydosilylation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-10-04 US disclosed
WO-2003062285-A1 VINYLAROMATIC POLYMERS HAVING HIGH MELT FLOW DOW GLOBAL TECHNOLOGIES, INC. (US) 2003-07-31 WO disclosed
US-6072085-A COMBINING SUBSTRATE IMINE, NUCLEOPHILIC ACTIVATOR, SILANE, METAL CATALYST, WHEREIN CATALYST CATALYZES REDUCTION OF IMINE BY HYDROSILATION MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-06-06 US disclosed
US-6013744-A ADDING A MONO- OR DIHYDROCARBYLSILANE ADJUVANT TO THE MONOMER MIXTURE AND CONTACTING UNDER POLYMERIZATION CONDITIONS WITH A GROUP 4 METAL COMPLEX OF GIVEN FORMULA AND ACTIVATING COCATALYST THE DOW CHEMICAL COMPANY (US) 2000-01-11 US disclosed
EP-0630933-B1 A method of producing a semiconducting material NIPPON OIL CO LTD (JP) 1999-04-14 EP disclosed
US-5700400-A Method for producing a semiconducting material NIPPON OIL CO., LTD. (JP) 1997-12-23 US disclosed
EP-0551771-B1 Process for producing polysilanes NIPPON OIL CO LTD (JP) 1997-07-30 EP disclosed
EP-0630933-A2 A method of producing a semiconducting material NIPPON OIL CO. LTD. (JP) 1994-12-28 EP disclosed
US-5304622-A Process for producing polysilanes NIPPON OIL COMPANY, LTD. (JP) 1994-04-19 US disclosed
EP-0551771-A2 Process for producing polysilanes NIPPON OIL CO. LTD. (JP) 1993-07-21 EP disclosed
US-4474976-A ARYLATION GENERAL ELECTRIC COMPANY (US) 1984-10-02 US disclosed