SCHEMBL1105491

SCHEMBL1105491

COC(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.75
EGFR P00533 1/20 0.72
PTPN1 P18031 1/20 0.69
MAPT P10636 4/20 0.63
RAB9A P51151 3/20 0.63
L3MBTL1 Q9Y468 2/20 0.63
PDCD1 Q15116 1/20 0.63
CD274 Q9NZQ7 1/20 0.63
CASP3 P42574 1/20 0.63
SENP8 Q96LD8 1/20 0.63
SENP7 Q9BQF6 1/20 0.63
SENP6 Q9GZR1 1/20 0.63
CA1 P00915 4/20 0.59
CA2 P00918 4/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CA12 O43570 2/20 0.59
CA9 Q16790 2/20 0.59
CA14 Q9ULX7 2/20 0.59
TDP1 Q9NUW8 1/20 0.59
CA7 P43166 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphine SCHEMBL28493400 0.98 TSHR (0.72) TSHREGFRPTPN1MAPTRAB9A
Phosphine SCHEMBL28496548 0.98 TSHR (0.72) TSHREGFRPTPN1MAPTRAB9A
SCHEMBL28495999 0.96 EGFR (0.73) TSHREGFRPTPN1MAPTRAB9A
SCHEMBL28931930 0.96 EGFR (0.73) TSHREGFRPTPN1MAPTRAB9A
Trimethylammonium SCHEMBL27715481 0.94 TSHR (0.67) TSHREGFRPTPN1MAPTRAB9A
Biphenyl SCHEMBL28575404 0.93 TSHR (0.86) TSHREGFRPTPN1MAPTRAB9A
SCHEMBL27589486 0.93 TSHR (0.64) TSHREGFRPTPN1MAPTRAB9A
Methyl Benzoate SCHEMBL28140701 0.92 TSHR (0.70) TSHREGFRPTPN1MAPTRAB9A
SCHEMBL19387238 0.91 CA1 (0.70) TSHREGFRPTPN1MAPTRAB9A
Biphenyl Dimethyl Dicarboxylate SCHEMBL68521 0.91 CA1 (0.70) TSHREGFRPTPN1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 419 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119912334-A Preparation method of p-pentoxy-terphenyl methyl formate and anidulafungin side chain 广东新达瑞生物科技有限公司 2025-05-02 CN claimed
CN-119661322-A Synthesis method of 4-diphenyl methanol 河北科技大学 2025-03-21 CN claimed
CN-118580198-A Dicarboxylic acid ligand containing benzothiadiazole functional group for preparing metal organic framework and preparation method thereof 江西理工大学 2024-09-03 CN claimed
WO-2023212597-A1 CARBON DIOXIDE CAPTURE AND UTILIZATION AS A CLEAN FEEDSTOCK MICHIGAN TECHNOLOGICAL UNIVERSITY (US) 2023-11-02 WO claimed
CN-115433204-A Synthetic method and application of spiro-expansible monomer with multi-benzene ring structure 深圳市安伯斯科技有限公司 2022-12-06 CN claimed
US-20220185785-A1 INHIBITORS OF CD40-CD154 BINDING TONIX Pharmaceuticals Holding Corp (US) 2022-06-16 US claimed
CN-107540848-B Preparation and application of efficient heterogeneous hydrogen bond donor MOF catalyst 合肥工业大学 2020-11-24 CN claimed
CN-106117048-A A kind of method synthesizing biphenyl 4 methyl formate 辽宁石油化工大学 2016-11-16 CN claimed
CN-104364246-A Piperidine derivatives useful as GPR119 agonists TOYOTA MOTOR CO LTD 2015-02-18 CN claimed
CN-102356068-B 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds HOFFMANN LA ROCHE 2014-04-23 CN claimed
US-5049496-A Method for microbiologically hydroxylating biphenyl and terphenyl compounds GENERAL ELECTRIC COMPANY (US) 1991-09-17 US claimed
WO-2026103887-A1 PROLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF 北京康辰药业股份有限公司 2026-05-21 WO disclosed
WO-2026098560-A2 BENZENE-CONTAINING POLYCYCLIC DERIVATIVE MODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2026-05-15 WO disclosed
US-12559455-B2 Compound as a UBR box domain ligand AUTOTAC INC. (KR) 2026-02-24 US disclosed
US-20250188626-A1 CARBON DIOXIDE CAPTURE AND UTILIZATION AS A CLEAN FEEDSTOCK UNIV MICHIGAN TECH (US) 2025-06-12 US disclosed
US-3980642-A 15-Substitute D-ω-pentanorprostaglandins PFIZER INC. (US) 1976-09-14 US disclosed
US-3974213-A 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins PFIZER INC. (US) 1976-08-10 US disclosed
US-3971826-A 15-Substituted-ω-pentanorprostaglandins PFIZER INC. (US) 1976-07-27 US disclosed
US-3956284-A INCREASED TISSUE SPECIFITY OF ACTION PFIZER INC. (US) 1976-05-11 US disclosed
US-3953466-A TETRAZOYL DERIVATIVES OF PROSTAGLANDINS PFIZER INC. (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220185785-A1 INHIBITORS OF CD40-CD154 BINDING CD40LG, CD40, CD4 TSHR 908/4885EGFR 2982/4885PTPN1 518/4885
US-12559455-B2 Compound as a UBR box domain ligand UBR4, UBTF, UBQLN1 TSHR 1240/4885EGFR 1402/4885PTPN1 1196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.