Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142722 | 0.87 | — | — | |
| SCHEMBL8978099 | 0.78 | GAA (0.70) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL15283000 | 0.77 | GAA (0.95) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3634814 | 0.77 | GAA (0.85) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3630393 | 0.77 | GAA (0.85) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3600256 | 0.75 | GAA (0.81) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL9987759 | 0.75 | GAA (0.81) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL1377365 | 0.73 | GAA (0.62) | GAAMEN1KMT2AHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL27685977 | 0.73 | GAA (0.77) | GAAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL8258944 | 0.73 | GAA (0.61) | GAAMEN1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |
| US-4452797-A | FOR CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1984-06-05 | — | — | US | disclosed |
| EP-0023343-B1 | SUBSTITUTED 3-AMINO-SYDNONIMINES, PROCESS FOR THEIR SYNTHESIS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CASSELLA Aktiengesellschaft (DE) | 1984-03-28 | — | — | EP | disclosed |
| US-4332801-A | HYPOTENSIVE; CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1982-06-01 | — | — | US | disclosed |
| US-4305939-A | HYPOTENSIVE | CASSELLA AG (DE) | 1981-12-15 | — | — | US | disclosed |
| EP-0023343-A2 | Substituted 3-amino-sydnonimines, process for their synthesis and pharmaceutical preparations containing them | CASSELLA Aktiengesellschaft (DE) | 1981-02-04 | — | — | EP | disclosed |