Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254460 | 0.88 | HTT (0.44) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11049975 | 0.84 | HTT (0.48) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11053981 | 0.83 | PDK1 (0.50) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11262102 | 0.83 | MAPK1 (0.43) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11052114 | 0.83 | PDK1 (0.50) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11050943 | 0.81 | HTT (0.44) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11050431 | 0.81 | HTT (0.51) | MAPK1KMT2AMEN1HTTKDM4E | |
| SCHEMBL11052077 | 0.81 | MEN1 (0.74) | MAPK1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL11053847 | 0.80 | HTT (0.49) | MAPK1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL11051610 | 0.80 | HTT (0.53) | MAPK1KMT2AMEN1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |