Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL86341 | 0.92 | PCSK9 (0.46) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL9220420 | 0.90 | MEN1 (0.46) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL3163216 | 0.90 | TDP1 (0.49) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL4270603 | 0.90 | TDP1 (0.49) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL4269209 | 0.90 | TDP1 (0.49) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL19628801 | 0.90 | MEN1 (0.46) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL17019827 | 0.90 | MEN1 (0.46) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL21004142 | 0.89 | PCSK9 (0.44) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL6518304 | 0.88 | MEN1 (0.45) | PCSK9MEN1GAAKMT2ATDP1 | |
| SCHEMBL21361608 | 0.88 | CA1 (0.46) | PCSK9MEN1GAAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019018186-A1 | METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2019-01-24 | — | — | WO | disclosed |
| US-8445611-B2 | Antimicrobial polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445611-B2 | Antimicrobial polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120195849-A1 | ANTIMICROBIAL POLYMERS | MIDCAP FINANCIAL SBIC, LP, AS ADMINISTRATIVE AGENT | 2012-08-02 | — | — | US | disclosed |
| US-8153739-B2 | Antimicrobial polymers | UNIVERSITY OF MASSACHUSETTS (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100317870-A1 | ANTIMICROBIAL POLYMERS | MIDCAP FINANCIAL SBIC, LP, AS ADMINISTRATIVE AGENT | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317870-A1 | ANTIMICROBIAL POLYMERS | CGAS, NOD2, NLRP1 | PCSK9 4441/4885MEN1 104/4885GAA 4206/4885 |
| US-20120195849-A1 | ANTIMICROBIAL POLYMERS | CGAS, NOD2, NLRP1 | PCSK9 4441/4885MEN1 104/4885GAA 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.