NOD2

Nucleotide-binding oligomerization domain-containing protein 2 · Q9HC29 · NOD2 on Sugi Atlas →

53,292 patent compounds predicted against NOD2, 36,461 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL188755	0.76	10/20
Pd-0166285 (SCHEMBL133914)	1.00	8/20
SCHEMBL125576	0.74	3/20
SCHEMBL127770	0.59	3/20
SCHEMBL189162	0.55	3/20
SCHEMBL127916	0.54	3/20
SCHEMBL127661	0.53	3/20
SCHEMBL188862	0.53	3/20
SCHEMBL125615	0.53	3/20
SCHEMBL127651	0.52	3/20
SCHEMBL63119	0.47	3/20
SCHEMBL188763	0.46	3/20
Paclitaxel (SCHEMBL3976)	1.00	2/20
Docetaxel Anhydrous (SCHEMBL4417)	1.00	2/20
Docetaxel Anhydrous (SCHEMBL4418)	1.00	2/20
Docetaxel Anhydrous (SCHEMBL4419)	1.00	2/20
Paclitaxel (SCHEMBL18997)	1.00	2/20
Paclitaxel (SCHEMBL125950)	1.00	2/20
Docetaxel Anhydrous (SCHEMBL177909)	1.00	2/20
Paclitaxel (SCHEMBL177944)	1.00	2/20

Clinical trials — most relevant to NOD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease	PHASE4	COMPLETED
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine	PHASE3	RECRUITING
Colchicine for Symptom and Inflammation in Knee Osteoarthritis	PHASE2/PHASE3	COMPLETED
Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING)	nan	COMPLETED
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Genetic Markers as Predictors of Phenotypes in Pediatric Onset Crohn's Disease	nan	WITHDRAWN
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases	nan	UNKNOWN
Infectious Agents in Pediatric Crohn's	nan	COMPLETED
Secondary Sclerosis Cholangitis Prospective	nan	RECRUITING
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED
Immunological Consequences of CARD15/NOD2 Mutations in Crohn's Disease	nan	COMPLETED
GWA Study in Patients With Inflammatory Bowel Disease	nan	RECRUITING
Nucleotide Protein -3 in Epileptic Children	nan	UNKNOWN
Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry	nan	COMPLETED
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease	nan	COMPLETED
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis	nan	COMPLETED
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
Search for New Genetic Mutations Major Effect in Crohn's Disease	nan	COMPLETED
Effective Treatment of Jak1/3 Inhibitor in Blau Syndrome	nan	ENROLLING_BY_INVITATION
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood	nan	COMPLETED
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis	nan	UNKNOWN
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)	nan	RECRUITING
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a NOD2 binder may also engage these)

Protein	Name	Similarity
Q53B88	—	1.000	Q53B88 →
Q53B87	—	1.000	Q53B87 →
Q6E804	—	1.000	Q6E804 →
G1T469	—	1.000	G1T469 →
Q8K3Z0	—	1.000	Q8K3Z0 →
Q8BHB0	—	0.995	Q8BHB0 →
NOD1	Nucleotide-binding oligomerization domain-containing protein 1	0.990	landscape →
Q86UT6	—	0.989	Q86UT6 →
Q3TL44	—	0.985	Q3TL44 →
C3VPR6	—	0.985	C3VPR6 →
Q5FVQ8	—	0.985	Q5FVQ8 →
P59044	—	0.977	P59044 →
Q647I9	—	0.977	Q647I9 →
Q9NX02	—	0.976	Q9NX02 →
Q91ZT7	—	0.976	Q91ZT7 →
P59046	—	0.976	P59046 →
Q149M9	—	0.975	Q149M9 →
Q8WX94	—	0.975	Q8WX94 →
Q9BXL6	—	0.973	Q9BXL6 →
A1IGU4	—	0.973	A1IGU4 →
Q9HB75	—	0.973	Q9HB75 →
P33076	—	0.972	P33076 →
B2RUP2	—	0.971	B2RUP2 →
Q63035	—	0.971	Q63035 →
Q8NE28	—	0.971	Q8NE28 →
Q8BTM9	—	0.970	Q8BTM9 →
Q14296	—	0.970	Q14296 →
Q6R653	—	0.970	Q6R653 →
Q6F5E8	—	0.970	Q6F5E8 →
Q96NS5	—	0.970	Q96NS5 →