SCHEMBL11058546

SCHEMBL11058546

CCc1cccc(CC)c1-n1cnc(NC2CC2)nc1=O

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 8/20 0.43
MKNK2 Q9HBH9 7/20 0.43
CDK4 P11802 2/20 0.41
CCND1 P24385 1/20 0.41
CCND2 P30279 1/20 0.41
CCND3 P30281 1/20 0.41
ADORA2A P29274 8/20 0.38
MAPK8 P45983 1/20 0.38
KDR P35968 1/20 0.38
ADORA1 P30542 5/20 0.37
MAPK14 Q16539 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11053183 0.93 CDK4 (0.38) MKNK1MKNK2CDK4CCND1CCND2
SCHEMBL11056495 0.88 CCND1 (0.42) MKNK1MKNK2CDK4CCND1CCND2
SCHEMBL11055859 0.87 MKNK1 (0.39) MKNK1MKNK2CDK4CCND1CCND2
SCHEMBL11055943 0.85 HCAR1 (0.41) MKNK1MKNK2CDK4CCND1CCND2
SCHEMBL11056006 0.82 KCNH2 (0.39) MKNK1MKNK2
SCHEMBL11057088 0.81 MEN1 (0.37) MKNK1MKNK2CDK4CCND1CCND2
SCHEMBL11051007 0.81 CDK4 (0.42) CDK4CCND1CCND2CCND3
SCHEMBL10540489 0.81 HCAR1 (0.39) MKNK1MKNK2
Hydrochloric Acid SCHEMBL11053509 0.81 KCNH2 (0.38) MKNK1MKNK2
SCHEMBL11052943 0.81 CDK4 (0.43) MKNK1MKNK2CDK4CCND1CCND2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4298608-A LOCAL ANESTHETICS WILLIAM H. RORER, INC. (US) 1981-11-03 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4203985-A Antidiarrheal triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203983-A GASTROINTESTINAL DISORDERS WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4203984-A Antisecretory triazinones WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4198408-A 1,4-DISUBSTITUTED-1,2-DIHYDRO-1,3,5-TRIHZIN-2-ONES WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed
US-4198409-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-04-15 US disclosed