Sugi Predict

Sugi Predict / Targets / HCAR1

HCAR1

Hydroxycarboxylic acid receptor 1 · Q9BXC0 · HCAR1 on Sugi Atlas →

12,571 patent compounds predicted against HCAR1, 5,114 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1786387 SCHEMBL1786387 0.88 12/20
SCHEMBL1788186 SCHEMBL1788186 1.00 10/20
SCHEMBL1784967 SCHEMBL1784967 0.83 10/20
SCHEMBL1788822 SCHEMBL1788822 0.79 10/20
SCHEMBL1787550 SCHEMBL1787550 1.00 7/20
SCHEMBL1788135 SCHEMBL1788135 1.00 7/20
SCHEMBL1787440 SCHEMBL1787440 0.90 7/20
SCHEMBL1784919 SCHEMBL1784919 0.87 7/20
SCHEMBL1786292 SCHEMBL1786292 0.84 7/20
SCHEMBL1787837 SCHEMBL1787837 0.74 7/20
SCHEMBL1785460 SCHEMBL1785460 0.72 7/20
SCHEMBL1791015 SCHEMBL1791015 0.72 7/20
SCHEMBL1786851 SCHEMBL1786851 0.69 7/20
SCHEMBL1437405 SCHEMBL1437405 0.49 7/20
SCHEMBL1787987 SCHEMBL1787987 0.76 6/20
SCHEMBL1788765 SCHEMBL1788765 0.64 6/20
SCHEMBL1784319 SCHEMBL1784319 0.54 6/20
SCHEMBL1868695 SCHEMBL1868695 0.40 6/20
SCHEMBL1785784 SCHEMBL1785784 1.00 5/20
SCHEMBL1787682 SCHEMBL1787682 0.85 5/20

Clinical trials — most relevant to HCAR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve PHASE2UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin PHASE2UNKNOWN
Intermittent Hypoxia and Caffeine in Infants Born Preterm PHASE2COMPLETED
Pilot Study of Pyridostigmine Upon Immune Activation in HIV-1 Patients Who Have an Inadequate Immune Response PHASE2COMPLETED
A Placebo-controlled Trial of Folinic Acid in Children With ASD PHASE2RECRUITING
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY PHASE1COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans. nanCOMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation nanCOMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients nanCOMPLETED
Gut Microbiome Analysis in Organ Transplant Recipient nanNOT_YET_RECRUITING
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis nanCOMPLETED
Molecular Evaluation of TAAR1 and JAK/STAT Pathway in Hidradenitis Suppurativa nanCOMPLETED
hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects nanCOMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling nanCOMPLETED
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care nanUNKNOWN
Gut Microbiota and Multiple Sclerosis nanUNKNOWN
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms nanCOMPLETED
Involvement of Pollutants in Atopic Dermatitis and Psoriasis nanUNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Individualized Antiretroviral Therapy nanCOMPLETED
Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy nanCOMPLETED
Omics-based Predictors of NAFLD/Potential NASH nanUNKNOWN
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management nanUNKNOWN
Characterizing a 5P-Linked BHR Susceptibility Locus nanCOMPLETED
Inflammation Impact on Pain in Knee Osteoarthritis nanCOMPLETED
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness nanUNKNOWN
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease nanCOMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance nanUNKNOWN
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HCAR1 binder may also engage these)

ProteinNameSimilarity
Q8C131 — 1.000 Q8C131 →
Q80Z39 — 0.993 Q80Z39 →
HCAR2 Hydroxycarboxylic acid receptor 2 0.992 landscape →
Q9EP66 — 0.990 Q9EP66 →
GPR174 Probable G-protein coupled receptor 174 0.987 landscape →
Q3U507 — 0.986 Q3U507 →
HCAR3 Hydroxycarboxylic acid receptor 3 0.984 landscape →
D4A7K7 — 0.982 D4A7K7 →
CYSLTR2 Cysteinyl leukotriene receptor 2 0.982 landscape →
F8VQN3 — 0.981 F8VQN3 →
B0UXR0 — 0.981 B0UXR0 →
Q3UJF0 — 0.980 Q3UJF0 →
Q3U6B2 — 0.980 Q3U6B2 →
P2RY10 Putative P2Y purinoceptor 10 0.979 landscape →
Q9Z282 — 0.979 Q9Z282 →
Q9XSD4 — 0.979 Q9XSD4 →
GPR55 G-protein coupled receptor 55 0.978 landscape →
P48042 — 0.978 P48042 →
Q61038 — 0.978 Q61038 →
GPR132 Probable G-protein coupled receptor 132 0.978 landscape →
B5X337 — 0.978 B5X337 →
A5PLE7 — 0.977 A5PLE7 →
P30558 — 0.977 P30558 →
P49650 — 0.977 P49650 →
D4A4Q2 — 0.977 D4A4Q2 →
Q09QM4 — 0.977 Q09QM4 →
Q6NS65 — 0.977 Q6NS65 →
Q924T8 — 0.977 Q924T8 →
P49652 — 0.976 P49652 →
Q8BLG2 — 0.976 Q8BLG2 →