Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323522 | 0.80 | KDM4E (0.50) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL894516 | 0.80 | KDM4E (0.50) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL22123202 | 0.79 | KDM4E (0.41) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL999646 | 0.78 | KDM4E (0.48) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL3598094 | 0.76 | KDM4E (0.46) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL5464811 | 0.76 | KDM4E (0.46) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL5989668 | 0.76 | KDM4E (0.46) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL5464814 | 0.76 | KDM4E (0.46) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL243962 | 0.74 | KDM4E (0.54) | KDM4EKMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL17556147 | 0.73 | KDM4E (0.43) | KDM4EKMT2AMAPTUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452797-A | FOR CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1984-06-05 | — | — | US | disclosed |
| EP-0023343-B1 | SUBSTITUTED 3-AMINO-SYDNONIMINES, PROCESS FOR THEIR SYNTHESIS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CASSELLA Aktiengesellschaft (DE) | 1984-03-28 | — | — | EP | disclosed |
| US-4332801-A | HYPOTENSIVE; CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1982-06-01 | — | — | US | disclosed |
| US-4305939-A | HYPOTENSIVE | CASSELLA AG (DE) | 1981-12-15 | — | — | US | disclosed |
| EP-0023343-A2 | Substituted 3-amino-sydnonimines, process for their synthesis and pharmaceutical preparations containing them | CASSELLA Aktiengesellschaft (DE) | 1981-02-04 | — | — | EP | disclosed |