Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810095 | 0.84 | HTR2A (0.66) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL6284545 | 0.80 | HTR2A (0.66) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL2170349 | 0.79 | HTR2A (0.70) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL14037582 | 0.79 | HTR2A (0.70) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL107852 | 0.79 | HTR2A (0.70) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL107851 | 0.79 | HTR2A (0.70) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL810131 | 0.77 | HTR2A (0.56) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL19586585 | 0.76 | HTR2A (1.00) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL19586755 | 0.76 | HTR2A (1.00) | HTR2AGRIK1GRIK2IDO1PAM | |
| SCHEMBL19586953 | 0.76 | HTR2A (1.00) | HTR2AGRIK1GRIK2IDO1PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486444-A | CARBONIC ANHYDRASE INHIBITORS | MERCK & CO., INC. (US) | 1984-12-04 | — | — | US | disclosed |
| US-4477466-A | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1984-10-16 | — | — | US | disclosed |