Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11170500 | 0.89 | MAPK1 (0.47) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11167920 | 0.88 | CHRM1 (0.40) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11065162 | 0.84 | CHRM1 (0.44) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12316373 | 0.80 | HTT (0.49) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11165251 | 0.79 | MAPT (0.41) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11064644 | 0.77 | MAPT (0.49) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11065996 | 0.77 | MAPK1 (0.46) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12316372 | 0.76 | GAA (0.52) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12316379 | 0.76 | MAPT (0.47) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11165675 | 0.76 | MAPT (0.43) | MAPK1LMNAMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451462-A | Method of treating inflammation and pain using heteramino benzofurans | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| US-4426380-A | ANTIINFLAMMATORY, ANALGESIC, SUNSCREEN | CIBA-GEIGY CORPORATION (US) | 1984-01-17 | — | — | US | disclosed |
| EP-0082109-A2 | Substituted 2-hydroxyphenylacetic acids and derivatives of them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | disclosed |
| EP-0078241-A2 | Furanes | CIBA-GEIGY AG (CH) | 1983-05-04 | — | — | EP | disclosed |