Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | GNPAT | O15228 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10454018 | 0.92 | DPP4 (0.41) | PTPN1ACEDPP4DPP8DPP9 | |
| SCHEMBL1083057 | 0.92 | DPP4 (0.41) | PTPN1ACEDPP4DPP8DPP9 | |
| SCHEMBL10453448 | 0.92 | DPP4 (0.41) | PTPN1ACEDPP4DPP8DPP9 | |
| SCHEMBL10453944 | 0.92 | DPP4 (0.41) | PTPN1ACEDPP4DPP8DPP9 | |
| SCHEMBL462747 | 0.92 | DPP4 (0.41) | PTPN1ACEDPP4DPP8DPP9 | |
| Water SCHEMBL11698272 | 0.90 | DPP4 (0.40) | PTPN1ACEBACE1DPP4DPP8 | |
| SCHEMBL30797948 | 0.89 | GNPAT (0.46) | PTPN1ACEGNPATBACE1DPP4 | |
| SCHEMBL30799921 | 0.86 | PTPN1 (0.45) | PTPN1ACEGNPATBACE1DPP4 | |
| SCHEMBL30408803 | 0.86 | PTPN1 (0.45) | PTPN1ACEGNPATBACE1DPP4 | |
| Hydrochloric Acid SCHEMBL11697790 | 0.83 | METAP2 (0.39) | PTPN1ACEGNPATBACE1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4465626-A | Process for preparation, isolation and purification of dipeptide sweeteners | PFIZER INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0074249-B1 | PROCESSES FOR PREPARATION, ISOLATION AND PURIFICATION OF DIPEPTIDE SWEETENERS | PFIZER INC. (US) | 1984-08-08 | — | — | EP | disclosed |
| EP-0074249-A1 | Processes for preparation, isolation and purification of dipeptide sweeteners | PFIZER INC. (US) | 1983-03-16 | — | — | EP | disclosed |
| US-4375430-A | Processes for preparation, isolation and purification of dipeptide sweeteners | PFIZER INC. (US) | 1983-03-01 | — | — | US | disclosed |