SCHEMBL11060729

SCHEMBL11060729

O=C1CSC(c2cccnc2)N1c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 1.00
POLB P06746 2/20 0.73
GFER P55789 4/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
CYP2C19 P33261 1/20 0.65
MAPT P10636 2/20 0.57
KMT2A Q03164 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
PTGS1 P23219 1/20 0.55
PTGS2 P35354 1/20 0.55
TDP1 Q9NUW8 1/20 0.54
NPSR1 Q6W5P4 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11149887 0.92 ALDH1A1 (0.85) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11056272 0.89 ALDH1A1 (0.80) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL10991756 0.88 ALDH1A1 (0.79) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11054061 0.88 ALDH1A1 (0.79) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11061005 0.88 ALDH1A1 (0.79) ALDH1A1POLBGFERCYP1A2CYP3A4
Hydrochloric Acid SCHEMBL11055508 0.87 ALDH1A1 (0.77) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11057653 0.86 POLB (0.77) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11059508 0.85 ALDH1A1 (0.74) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11059953 0.85 ALDH1A1 (0.79) ALDH1A1POLBGFERCYP1A2CYP3A4
SCHEMBL11057486 0.85 GFER (0.76) ALDH1A1POLBGFERCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4482712-A FUNGICIDES; HERBICIDES; PLANT GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1984-11-13 US disclosed
US-4436739-A FUNGICIDES ELI LILLY AND COMPANY (US) 1984-03-13 US disclosed
EP-0010420-A1 Pyridyl-substituted thiazolidine and 1,3-thiazine derivatives, processes for their preparation, agricultural compositions containing said derivatives and methods for regulating plant growth and protecting plants from fungi ELI LILLY AND COMPANY (US) 1980-04-30 EP disclosed