SCHEMBL11061985

SCHEMBL11061985

CCCC[C@H]1CC[C@H](CCc2ccc(C(=O)OC)cc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4A11 Q02928 2/20 0.54
CYP4F2 P78329 1/20 0.52
LOXL2 Q9Y4K0 1/20 0.46
HRH1 P35367 1/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NPC1 O15118 1/20 0.44
CASP1 P29466 1/20 0.44
RAB9A P51151 1/20 0.44
GRM2 Q14416 1/20 0.44
KDM4E B2RXH2 1/20 0.43
CYP1A2 P05177 3/20 0.43
CYP3A4 P08684 3/20 0.43
CYP2C19 P33261 3/20 0.43
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.43
PLK1 P53350 1/20 0.43
CYP2C9 P11712 2/20 0.43
TP53 P04637 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11061983 1.00 CYP4A11 (0.54) CYP4A11CYP4F2LOXL2HRH1MEN1
SCHEMBL11060365 0.96 CYP4A11 (0.52) CYP4A11CYP4F2LOXL2HRH1MEN1
SCHEMBL11060372 0.96 CYP4A11 (0.52) CYP4A11CYP4F2LOXL2HRH1MEN1
SCHEMBL11065186 0.95 CYP4A11 (0.51) CYP4A11CYP4F2LOXL2HRH1GRM2
SCHEMBL11065191 0.95 CYP4A11 (0.51) CYP4A11CYP4F2LOXL2HRH1GRM2
SCHEMBL11058919 0.95 CYP4A11 (0.51) CYP4A11CYP4F2LOXL2HRH1GRM2
SCHEMBL11058923 0.95 CYP4A11 (0.51) CYP4A11CYP4F2LOXL2HRH1GRM2
SCHEMBL11064341 0.92 CYP4A11 (0.49) CYP4A11CYP4F2LOXL2HRH1MEN1
SCHEMBL11064346 0.92 CYP4A11 (0.49) CYP4A11CYP4F2LOXL2HRH1MEN1
SCHEMBL11061734 0.92 CYP4A11 (0.53) CYP4A11CYP4F2LOXL2HRH1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4439015-A Disubstituted ethanes HOFFMANN-LA ROCHE INC. (US) 1984-03-27 US disclosed