Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683637 | 1.00 | ACE (0.67) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL683641 | 0.90 | ACE (0.73) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL11190530 | 0.89 | ACE (0.62) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL11062272 | 0.86 | ACE (0.66) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL11186340 | 0.86 | ACE (0.50) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL11059109 | 0.85 | ACE (0.65) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL683176 | 0.85 | ACE (0.58) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL683282 | 0.85 | GAA (0.70) | ACEGAAPOLBRAB9AHSD17B10 | |
| SCHEMBL11385050 | 0.81 | ACE (0.61) | ACEGAAPOLBRAB9AHSD17B10 | |
| Rentiapril SCHEMBL294980 | 0.80 | ACE (1.00) | ACEPOLBHSD17B10FFAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430344-A | Antihypertensive 4-thiazolidinecarboxylic acids | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-02-07 | — | — | US | claimed |
| JP-56081691-A | — | — | None | — | — | JP | disclosed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |
| JP-S5681691-A | MANUFACTURE OF THIOL COMPOUND | SANTEN PHARMACEUT CO LTD | 1981-07-03 | — | — | JP | disclosed |