SCHEMBL11063295

SCHEMBL11063295

O=C(O)CC(O)(C(=O)O)C(Cl)C(=O)O.[NaH].[NaH]

nearest known ligand 0.96

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACLY P53396 5/20 0.57
CPT2 P23786 1/20 0.57
HSPD1 P10809 1/20 0.43
BLM P54132 1/20 0.43
HSPE1 P61604 1/20 0.43
ALDH1A1 P00352 1/20 0.41
HMGCR P04035 1/20 0.36
CHRM1 P11229 1/20 0.36
TBXA2R P21731 1/20 0.36
ADRA1A P35348 1/20 0.36
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
HIF1A Q16665 1/20 0.34
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1672954 0.98 ACLY (0.59) ACLYCPT2HSPD1BLMHSPE1
Ammonia Solution, Strong SCHEMBL11158969 0.96 ACLY (0.57) ACLYCPT2HSPD1BLMHSPE1
Water SCHEMBL8023706 0.96 ACLY (0.57) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL23068539 0.76 ACLY (0.95) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL887088 0.76 ACLY (0.95) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL23068481 0.76 ACLY (0.95) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL2190166 0.75 ACLY (0.64) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL28318764 0.74 ACLY (0.57) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL17181757 0.73 ACLY (1.00) ACLYCPT2HSPD1BLMHSPE1
SCHEMBL721435 0.73 ACLY (1.00) ACLYCPT2HSPD1BLMHSPE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4443619-A MULTISTEP PREPARATION OF MONOPOTASSIUM DIHYDROGEN THREO-EPOXYACONITATE FROM TRANSACONITIC ACID HOFFMANN-LA ROCHE INC. (US) 1984-04-17 US disclosed
US-4365070-A B-LACTONE INTERMEDIATES THEREOF, ANORECTIC AGENTS FOR TREATMENT OBESITY HOFFMANN-LA ROCHE INC. (US) 1982-12-21 US disclosed
US-4354039-A Chlorocitric acids HOFFMANN-LA ROCHE INC. (US) 1982-10-12 US disclosed
US-4352758-A FROM TRANS-ACONITIC ACID HOFFMANN-LA ROCHE INC. (US) 1982-10-05 US disclosed
US-4340754-A Process for making chlorocitric acid HOFFMANN-LA ROCHE INC. (US) 1982-07-20 US disclosed
US-4312885-A ANORECTIC AGENTS FOR TREATMENT OF OBESITY HOFFMANN-LA ROCHE INC. (US) 1982-01-26 US disclosed