Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401 | 1.00 | MAPK1 (0.48) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5180 | 0.91 | MAPK1 (0.55) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4518 | 0.91 | MAPK1 (0.52) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5752 | 0.91 | MAPK1 (0.55) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5270 | 0.91 | MAPK1 (0.55) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL20103183 | 0.78 | MAPK1 (0.42) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5765 | 0.78 | KDM4E (0.51) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5949120 | 0.76 | POLB (0.38) | MAPK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL28108062 | 0.75 | KMT2A (0.40) | MEN1KMT2AMAPTL3MBTL1LMNA | |
| SCHEMBL10203579 | 0.74 | POLB (0.36) | MAPK1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488493-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045292-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-21 | — | — | WO | disclosed |