Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752 | 0.86 | MAPK1 (0.55) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL5180 | 0.86 | MAPK1 (0.55) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL5270 | 0.86 | MAPK1 (0.55) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL3815209 | 0.80 | POLB (0.36) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL3815212 | 0.80 | POLB (0.36) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL10203579 | 0.80 | POLB (0.36) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL11064 | 0.78 | MAPK1 (0.48) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL10401 | 0.78 | MAPK1 (0.48) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL19631749 | 0.78 | POLB (0.35) | MAPK1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL26704563 | 0.75 | SLC6A4 (0.35) | MAPK1KDM4EKMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |