Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061284 | 0.78 | CNR2 (0.43) | RAB9ANPC1SMN1; SMN2MAPTLMNA | |
| SCHEMBL3823123 | 0.78 | MEN1 (0.52) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL11059486 | 0.77 | STS (0.53) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL31414638 | 0.77 | CES2 (0.77) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL4823687 | 0.77 | CES2 (0.77) | RAB9AMEN1KMT2ANPC1CES2 | |
| Hydrochloric Acid SCHEMBL27733557 | 0.75 | CES2 (0.74) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL11871480 | 0.74 | CES2 (0.57) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL11868641 | 0.73 | MEN1 (0.56) | RAB9AMEN1KMT2ANPC1CES2 | |
| SCHEMBL6389792 | 0.72 | MEN1 (0.82) | RAB9AMEN1KMT2ANPC1TSHR | |
| SCHEMBL6395697 | 0.72 | MEN1 (0.73) | RAB9AMEN1KMT2ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4458081-A | ANTIINFLAMMATORY, ANALGESIC, ANTICOAGULANT, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1984-07-03 | — | — | US | disclosed |
| US-4454326-A | 5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates | SYNTEX (U.S.A.) INC. (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0105288-A1 | CARBACYCLINE, PREPARATION AND UTILIZATION THEREOF. | SCHERING AG (DE) | 1984-04-18 | — | — | EP | disclosed |
| WO-1983003248-A1 | CARBACYCLINE, PREPARATION AND UTILIZATION THEREOF | VORBRÜGGEN, Helmut | 1983-09-29 | — | — | WO | disclosed |
| US-4347187-A | Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein | SYNTEX (U.S.A.) INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347186-A | Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein | SYNTEX (U.S.A.) INC. (US) | 1982-08-31 | — | — | US | disclosed |